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Application of Fatty Acids as Antiviral Agents Against Tobacco Mosaic Virus

Lei Zhao, Yujia Chen, Kuan Wu, He Yan, Xingan Hao, Yunfeng Wu.

Pesticide Biochemistry and Physiology

DOI:10.1016/j.pestbp.2017.05.005

 

 

Abstract:Numer ous studies reported fattyacids (FAs) affectingbasalresistancetobacterialandfungalpathogensinplants,but limited reports focused on antiviral agents. In this study, oleic acid was separated from cottonseed oil sludge byantiviral bioassay-guidedmethods. Antiviral activity of FAs wascompared with that ofNingnanmycin. Subse-quently, effects of FAs on defense-related enzymes (PAL, POD) and defense-related genes (PR-1a, PR-5) were studied. FAs presented moderate antiviral activity, which is close to that of Ningnanmycin, and activities of PAL and POD were higher in oleic-acid-treated tobacco leaves than those inoculated with tobacco mosaic virus (TMV) and water-treated tobacco. In oleic-acid-treated tobacco, expression levels of PR-1a and PR-5 genes rap idlyincreasedfrom days 1–3.All results showedthat FAs canincreaseresistanceagainst TMV,and relatedmechanism can be attributed to activated expressions of a number of defense-related genes, suggesting that FAs can potentially act as pesticides for integrated control of plant viruses in the future.